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A Study of Minimal Hepatic Encephalopathy in Patients with Cirrhosis of Liver – A Hospital Based Study
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A Study of Minimal Hepatic Encephalopathy in Patients with Cirrhosis of Liver – A Hospital Based Study
Dr Robertson Timung, Dr Rima Moni Doley, Dr Sudeep Saha, Dr Ashim Chamuah, Dr Moumita Sen, Dr Udayan Borborah
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Abstract
Hepatic encephalopathy is a serious complication of chronic liver disease characterized by the presence of various states of altered mental status, ranging from mild alteration in sleep wake cycle to obtundation and deep coma.
Minimal hepatic encephalopathy is defined as early stage of hepatic encephalopathy without symptoms on clinical and neurological examination but with mild cognitive impairment and attention deficits.
Various combination of psychomotor test has been assessed for their use in diagnosis of minimal hepatic encephalopathy.
Aim : To study the Proportion of patients presenting with minimal hepatic encephalopathy in cirrhosis liver and also to find out the correlation between results of psychometric tests.
Result : Age Distribution of 120 patients showed majority of the patients were in age group of 31- 40 years and gender distribution showed 92.5% were males. Majority of the patients had alcoholic cirrhosis as the etiology (79.1%). Among the clinical features distension of the abdomen was the most common symptoms and among the clinical signs pallor (55%) was the most common, followed by splenomegaly (48.33%). On calculating Child Pugh’s score it was seen that 44.17% patients were in Child Class B. Minimal hepatic encephalopathy was found to be highest in Child Pugh Class B (56.6%). Patients with minimal hepatic encephalopathy with gastro esophageal varices and was found to be statistically significant (P-value <0.001).
Conclusion : The single centered cross-sectional observational hospital-based study performed with 120 cases of cirrhosis of liver without overt hepatic encephalopathy showed majority of patients have abnormal psychometric test- number connection test (NCT A), digital symbol test etc
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