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Histopathological Study of Soft Tissue Tumors in a Tertiary Care Hospital
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Histopathological Study of Soft Tissue Tumors in a Tertiary Care Hospital
Dr. Himali Makwana, Dr. Ashwini Shukla, Dr. Niketa Roy, Dr. Suchi Godhani, Dr. Neha Pandya
DOI
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Abstract
Introduction : Soft tissue refers to non-epithelial tissue, Soft tissue is a specialized form of tissue derived from the mesenchymal component of the embryo. It includes adipose tissue, fibrous tissue, skeletal muscles, blood vessels, lymphatic vessels and peripheral nervous system and is exclusive of skin, bone, lymphoreticular system, glia and soft tissues of various parenchymal organs. Soft tissue tumors (STT) are categorized into benign, intermediate and malignant. The incidence of benign STT is higher when compared to malignant tumors. Histopathology is considered the gold standard method for the diagnosis of soft tissue tumors. Different special stains along with Immunohistochemistry are applied to increase the diagnostic accuracy of soft tissue tumors.
Material and Method : The study was conducted on soft tissue tumors over the period from July 2022 to December 2023, with a total of 189 cases in the Department of Pathology.
Results : : A total of 189 soft tissue tumor biopsy specimens were received in the pathology department including the age range 1 to 60 years and gender (Male/Female). Most common age group is 20-40 years (40.74%). Among them most of tumors are Benign 169(89.41%), some are Malignant 20(10.58%). The most common benign soft tissue tumor were Leiomyoma ,Lipoma , Hemangioma , Schwannoma and Lymphangioma, Angiomyolipoma, desmoid tumor, nodular fasciitis , glomangiopericytoma, benign fibrous histiocytoma. The most common benign soft tissue tumor was Leiomyoma 74(39.15%), followed by Lipoma 40(21.16%).Benign soft tissue tumors showed female preponderance with peak incidence in 3rd and 4th decade. Malignant tumor was Dermatofibrosarcoma protuberance , malignant fibrous histiocytoma, liposarcoma, fibrosarcoma, leiomyosarcoma, smooth muscle tumor of uncertain malignant potential, epithelioid sarcoma, primitive neuroectodermal tumor, solitary fibrous tumor, undifferentiated sarcoma.
Conclusion : Benign soft tissue tumors were relatively more common than the malignant tumors. Leiomyoma was the commonest benign soft tissue tumor followed by Lipoma. Histopathological diagnosis of soft tissue tumors is important for further management of patients. Histopathological study along with IHC wherever necessary , should go hand in hand to make an effective and complete diagnosis of soft tissue tumors
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